Sherlock Holmes and Dr John Watson find themselves in Canada investigating a series of gruesome murders supposedly perpetrated by a supernatural creature.
- Basil Rathbone as Sherlock Holmes.
- Nigel Bruce as Dr John Watson
- Gerald Hamer as Alistair Ramson
- Paul Cavanaugh as William Penrose
- Arthur Hohl as Emile Journet
The Scarlet Claw is considered by many fans to be the finest of the twelve Universal Pictures Sherlock Holmes films.