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Sussex is a county in South East England.
- In "His Last Bow", Sherlock Holmes has retired to a small farm on the Sussex Downs.
- In The Valley of Fear Holmes travels with Dr Watson and Inspector Alec MacDonald to Birlstone village in Sussex to investigate the murder of John Douglas at Birlstone House.
- "The Adventure of the Sussex Vampire" takes place here.
- The film, A Slight Trick of the Mind, features a retired Holmes living in a Sussex village.